Table 5.

The interactions of SNPs on depression.

Depression phenotypes	Gut microbiome	Gut microbiome related SNPs		IBD related SNPs		SNP × SNP interaction P value
		ID	Gene locus	ID	Gene locus
PHQ-9 score
	G_Alloprevotella_HB	rs139744914	OBP2B	rs911359	LINC01620	4.77 × 10−4
		rs147650986	GPM6A	rs114471990	QRICH1	2.26 × 10−4
		rs148583470	3p12.1	rs76970129	18p11.21	8.43 × 10−4
		rs77408394	CACNA1C	rs28894977	6p21.33	7.00 × 10−4
	G_Aestuariispira_HB	rs10882795	TLL2	rs2517523	HCG22	1.01 × 10−4
				rs939983	15q13.1	1.25 × 10−4
				rs9262636	HCG22	4.03 × 10−4
				rs2517474	6p21.33	8.03 × 10−4
		rs140132254	FER1L6	rs3809133	ESYT1, ZC3H10	4.89 × 10−4
	G_Anaerostipes_RNT	rs117662630	14q21.1	rs114471990	QRICH1	1.02 × 10−4
				rs147118406	C3orf84	1.61 × 10−4
Self-reported depression
	G_Alloprevotella_HB	rs181338468	4q31.21	rs911359	LINC01620		2.35 × 10−4
				rs2844670	6p21.33		3.67 × 10−4
	G_Aestuariispira_HB	rs140132254	FER1L6	rs9262636	HCG22		5.14 × 10−4
	P_Firmicutes_RNT	rs11788336	ELP1	rs2254210	VDR		9.73 × 10−4
Age at first episode of depression
	G_Alloprevotella_HB	rs147377160	2q14.3	rs9308261	1p13.2			1.41 × 10−4
		rs147650986	GPM6A	rs11564168	MUC19,AC107023.1			5.73 × 10−4
		rs181338468	4q31.21	rs117987337	12q12			7.95 × 10−4
	F_Veillonellaceae_HB	rs117748831	16p13.2	rs11168249	HDAC7			5.39 × 10−4
Depression possibly related to childbirth
	G_Alloprevotella_HB	rs116712055	WDR64	rs117987337	12q12			1.06 × 10−4
		rs78681519	SLC13A3	rs1538580	9q21.11			4.87 × 10−4
		rs9282699	CSHL1,GH1	rs2853564	VDR,AC121338.1			6.39 × 10−4
	P_Firmicutes_RNT	rs11788336	ELP1	rs12179536	MUC22			9.88 × 10−4
	G_Dialister_HB	rs10249533	PDE1C	rs10401439	SYMPK			3.06 × 10−4
		rs11001120	10q22.2	rs3213673	DLD,LAMB1			1.40 × 10−4

Notes: P, Phylum. F, Family. G, Genus. SNP: Single nucleotide polymorphisms. PHQ: Patient Health Questionnaire. IBD: Inflammatory bowel disease.