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. 2022 Oct 7;8(6):453–464.

Table S3. Microscopic changes scoring matrix.

Score Anastomosis integrity
0 Intact, no defect
1 Defect restricted to mucosa/submucosa
2 Defect extends to muscularis externa
3 Defect extends to adventitia
4 Regional peritoneal involvement

Score Tissue proliferation

0 Absent
1 Minimal, immature tissue restricted to edges of anastomosis
2 Mild with involvement of <50% of anastomosis
3 Mild with involvement of >50% of anastomosis
4 Marked, diffuse tissue repair and maturation

Score Inflammation

0 Absent
1 Rare, minimal, ~1-5/per high power field (hpf; 40x obj)
2 Mild, multifocal or locally extensive ~5—10/hpf
3 Moderate confluent infiltrate with preservation of normal tissue architecture
4 Packed, overwhelming infiltrate with effacement of regional architecture

Score Necrosis

0 Absent
1 Minimal, focal, nearly imperceptible
2 Mild, focally extensive, inconspicuous
3 Moderate, multifocal or locally extensive, readily apparent
4 Severe, regionally extensive, overwhelming with effacement of regional architecture

Score Fibrosis

0 Absent
1 Minimal, e.g., narrow band, ~1—2 cell layers thick
2 Mild, e.g., thin, localized band, <~10 cell layers thick
3 Moderately thick, contiguous band along length of tissue/ structure
4 Extensive zone with regional extension effacement of local architecture