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. 2022 Aug 22;4(8):CASE22212. doi: 10.3171/CASE22212

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FIG. 2. — Case 1. Hematoxylin and eosin–stained section illustrates reactive astrocytes and macrophages in the brain parenchyma and a perivascular accumulation of lymphocytes and macrophages (A). The myelin stain (Klüver Barrera) documents diminution of myelin (B); neurofilament immunostain identifies intact axons (C); glial fibrillary acid protein highlights long stellated processes of reactive astrocytes (D); many perivascular lymphocytes are T lymphocytes (CD3 [E], CD4 [F], and CD8 [G] immunohistochemistry); and CD68 immunohistochemistry (H) highlights parenchymal macrophages.