Table 5. Evidence for impact of family-centred care on child and adolescent tuberculosis diagnosis, treatment and prevention outcomes.
| Type of outcome, care delivery approach | Author | Intervention condition outcomes | Control condition outcomes | Effect estimate (95% Cl) |
|---|---|---|---|---|
| Diagnosis | ||||
| Support | Htet et al., 201853 | 10/59 (17%) contacts diagnosed with tuberculosis | NA | NA |
| Imsanguan., et al., 202054 | 3/48 (6%) contacts diagnosed with tuberculosis | NA | NA | |
| Choice | Kay et al., 202265 | 3/492 (1%) contacts diagnosed with tuberculosis | NA | NA |
| Treatment | ||||
| Support | Demissie et al., 200355 | 5/7 (71%) patients with treatment success | NA | NA |
| Oyieng’o et al., 201256 | 1/1 (100%) MDR-tuberculosis patient with treatment success | NA | NA | |
| Satti et al., 201257 | 15/17 (88%) MDR-tuberculosis patients with treatment success | NA | NA | |
| Wai et al., 201758 | 1/1 (100%) MDR-tuberculosis patient with treatment success | NA | NA | |
| Choice | Dick et al., 199659 | 148/203 (73%) patients classified as adherent | NA | NA |
| Soomro et al., 201260 | 14/14 (100%) patients with treatment success | NA | NA | |
| van den Boogaard et al., 200961 | 245/308 (80%) patients with treatment success | NA | NA | |
| Support and choice | Mesic et al., 202062 | 8/11 (73%) patients with rifampicin-resistant tuberculosis with treatment success | NA | NA |
| Prevention | ||||
| Support | Wingfield et al., 201742 | 91/206 (44%) identified contacts initiated preventive treatment | 53/206 (26%) identified contacts initiated preventive treatment | RR: 1.70 (1.10–2.64) |
| Rocha et al., 201143 | 477/542 (88%) identified contacts initiated preventive treatment | 1116/2929 (39%) identified contacts initiated preventive treatment | RR: 2.23 (2.11–2.36) | |
| 383/441 (87%) contacts completed preventive treatment | 301/1116 (27%) contacts completed preventive treatment | RR: 3.22 (2.90–3.57) | ||
| Yuen et al., 201963 | 57/140 (41%) identified contacts initiated preventive treatment | NA | NA | |
| 51/57 (89%) contacts completed preventive treatment | NA | NA | ||
| Choice | Triasih et al., 201664 | 86/99 (87%) eligible contacts initiated preventive treatment | NA | NA |
| 50/86 (58%) contacts completed preventive treatment | NA | NA | ||
| Kay et al., 202265 | 237/248 (96%) contacts completed preventive treatment | NA | NA | |
CI: confidence interval; MDR: multidrug resistant; NA: not applicable; RR: risk ratio.
Note: We defined children and adolescents as people 0–19 years old, but individual studies focused on different age groups within this range.