Table 2. Standardized Mortality Ratios for Pediatric ALL in Sweden.
| Characteristic | Deaths among pediatric patients with ALL, No. | Expected deaths in the general population, No. | Standardized mortality ratio (95% CI) |
|---|---|---|---|
| Overall mortality | |||
| All | 409 | 9.5 | 43.1 (39.0-47.5) |
| Females | 171 | 3.0 | 57.8 (49.5-67.2) |
| Males | 238 | 6.5 | 34.5 (32.0-41.4) |
| Age at ALL diagnosis, y | |||
| 0-4 | 154 | 4.4 | 35.0 (29.7-41.0) |
| 5-10 | 94 | 2.0 | 46.9 (37.9-57.4) |
| 11-15 | 105 | 2.0 | 52.3 (42.8-63.4) |
| 16-17 | 56 | 1.1 | 52.2 (39.4-67.7) |
| Date at ALL diagnosisa | |||
| 1988-1991 | 56 | 0.5 | 114.8 (86.7-149.1) |
| 1992-1999 | 91 | 0.8 | 111.8 (90.0-137.3) |
| 2000-2007 | 90 | 0.7 | 132.6 (106.6-163.0) |
| 2008-2013 | 71 | 0.7 | 109.3 (85.3-137.8) |
| Cause-specific mortality, ICD-10 chapterb | |||
| 1 | 2 | 0.1 | 15.0 (1.8-54.2) |
| 2 | |||
| All | 382 | 1.2 | 327.6 (295.5-362.1) |
| Females | 161 | 0.5 | 334.7 (285.0-390.6) |
| Males | 221 | 0.7 | 322.5 (281.4-368.0) |
| 3 | 3 | 0.1 | 55.4 (11.4-161.8) |
| 9 | 2 | 0.5 | 4.4 (0.5-16.0) |
| 10 | 3 | 0.2 | 19.3 (4.0-56.3) |
| 17 | 3 | 0.8 | 4.0 (0.8-11.6) |
| 18 | 7 | 0.5 | 13.4 (5.4-27.7) |
| 20 | 5 | 4.5 | 1.1 (0.4-2.6) |
| Specific cause of mortality | |||
| Hematologic malignant tumors | |||
| All | 356 | 0.2 | 1551.1 (1394.1-1720.9) |
| Females | 150 | 0.1 | 1878.4 (1589.9-2204.3) |
| Males | 206 | 0.2 | 1376.4 (1198.5-1577.8) |
| Brain tumors | 4 | 1.1 | 15.4 (4.2-39.3) |
Abbreviations: ALL, acute lymphoblastic leukemia; ICD-10, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision.
a
All patients had 4 years of follow-up except those who died during the study period.
b
ICD-10 chapters: 1, certain infectious and parasitic diseases; 2, neoplasms; 3, diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism; 9, diseases of the circulatory system; 10, diseases of the digestive system; 17, congenital malformations, deformations, and chromosomal abnormalities; 18, symptoms, signs, and abnormal clinical and laboratory findings, not elsewhere classified; and 20, external causes of morbidity.