. Author manuscript; available in PMC: 2022 Nov 29.

Published in final edited form as: Psychoneuroendocrinology. 2022 Jul 15;144:105868. doi: 10.1016/j.psyneuen.2022.105868

Table 3.

Effect size estimation

Child Mitochondrial Measures	Low Maternal Allostatic Load			High Maternal Allostatic Load			Cohen’s D effect size (median AL split)	Correlation with Maternal Allostatic Load r (p-value)
Child Mitochondrial Measures	Mean	SD	N	Mean	SD	N	Cohen’s D effect size (median AL split)	Correlation with Maternal Allostatic Load r (p-value)

CS	111.2	26.4	15	142.2	48.9	15	0.789	0.47 (0.009)
mtDNAcn	368.4	80.1	15	446.4	128.6	15	0.729	0.44 (0.014)
Complex I	8.6	2.9	15	11	3.4	15	0.766	0.43 (0.019)
Complex II	53.7	20.3	15	75.7	33.1	15	0.802	0.46 (0.011)
Complex IV	14.2	4.2	15	19.1	7	15	0.854	0.48 (0.008)

Maternal allostatic load was divided into a “high” and “low” allostatic load (by a median split), and a Cohen’s D effect size was calculated to examine the magnitude of the relationship between high vs. low maternal allostatic load and offspring mitochondrial content and mitochondrial bioenergetic capacity (enzymatic activity indexed per cell). Additionally, the Pearson correlation (r) with p-value was calculated to further examine the magnitude of the linear association between maternal allostatic load and mitochondrial content, and mitochondrial bioenergetic capacity (enzymatic activity indexed per cell). AL= maternal allostatic load; CS= citrate synthase; mtDNAcn= mitochondrial DNA copy number; CI= complex I; CII= complex II; CIV= complex IV.