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. 2022 Nov 25;23:328–342. doi: 10.1016/j.bioactmat.2022.11.011

Fig. 4.

Fig. 4

C-EVs-siRNA promotes motor function recovery after SCI in mice. (A) Schematic diagram of experimental design. (B, C) BMS scores of mice treated with PBS, EVs, EVs-siRNA or C-EVs-siRNA during the recovery period 28 days after injury. (D, E) Typical diagrams of footprint tests in mice treated with PBS, EVs, EVs-siRNA or C-EVs-siRNA on day 28 after injury. (F) Rotarod test on day 28 after injury in the indicated groups. (G) Electrophysiological assessment with MEP analysis on day 28 post-injury (arrows indicate onset of evoked potentials). (H) Quantification of peak-to-peak MEP amplitude and latency in mice in the indicated treatment groups. *P < 0.05; **P < 0.01; ***P < 0.001 (n = 6 per group).