Table 1.
Risk of major outcomes according to the adherence to the ABC pathway (n = 24,608).
| Outcome | Number of criteria |
0-1 vs. 2–3 criteria |
Full vs. incomplete adherence |
|||||
|---|---|---|---|---|---|---|---|---|
| 0 criteria (n = 707) (Ref.) |
1 criteria (n = 5285) aHR [95% CI]a |
2 criteria (n = 12,112) aHR [95% CI]a |
3 criteria (n = 6504) aHR [95% CI]a |
0-1 criteria (n = 5992) (Ref.) |
2-3 criteria (n = 18,616) aHR [95%CI]a |
Incomplete adherence (n = 18,104) (Ref.) |
Full adherence (n = 6504) aHR [95%CI]a |
|
| Primary outcome | ||||||||
| All-cause death and MACE | Ref. | 0.69 [0.57–0.84] | 0.58 [0.48–0.70] | 0.54 [0.44–0.67] | Ref. | 0.79 [0.72–0.86] | Ref. | 0.87 [0.79–0.97] |
| Secondary outcomes | ||||||||
| All-cause death | Ref. | 0.73 [0.58–0.92] | 0.61 [0.49–0.76] | 0.58 [0.46–0.74] | Ref. | 0.79 [0.72–0.87] | Ref. | 0.89 [0.79–1.00] |
| CV death | Ref. | 0.62 [0.45–0.87] | 0.46 [0.33–0.65] | 0.44 [0.30–0.64] | Ref. | 0.69 [0.59–0.82] | Ref. | 0.84 [0.68–1.04] |
| Stroke | Ref. | 0.71 [0.47–1.08] | 0.63 [0.42–0.95] | 0.51 [0.33–0.79] | Ref. | 0.81 [0.67–0.97] | Ref. | 0.77 [0.62–0.95] |
| Thromboembolism | Ref. | 0.74 [0.51–1.07] | 0.65 [0.46–0.93] | 0.54 [0.37–0.79] | Ref. | 0.81 [0.69–0.95] | Ref. | 0.78 [0.65–0.94] |
| MACE | Ref. | 0.64 [0.50–0.82] | 0.52 [0.40–0.66] | 0.46 [0.35–0.60] | Ref. | 0.74 [0.66–0.84] | Ref. | 0.82 [0.71–0.95] |
| Myocardial infarction | Ref. | 0.69 [0.43–1.11] | 0.59[0.37–0.93] | 0.64 [0.38–1.06] | Ref. | 0.82 [0.65–1.03] | Ref. | 1.01 [0.77–1.33] |
| Major bleeding | Ref. | 1.01 [0.63–1.61] | 1.10 [0.70–1.74] | 1.11 [0.69–1.78] | Ref. | 1.10 [0.92–1.31] | Ref. | 1.04 [0.87–1.24] |
| All-cause death, stroke, and major bleeding | Ref. | 0.78 [0.64–0.96] | 0.69 [0.57–0.85] | 0.67 [0.54–0.82] | Ref. | 0.86 [0.79–0.93] | Ref. | 0.92 [0.83–1.01] |
| All-cause death, MACE, and major bleeding | Ref. | 0.75 [0.62–0.91] | 0.67 [0.56–0.80] | 0.64 [0.53–0.78] | Ref. | 0.85 [0.78–0.92] | Ref. | 0.92 [0.83–1.01] |
Bold text depicts statistically significant results at p < 0.05 level.
aHR = adjusted hazard ratio; CI = confidence interval; CV = cardiovascular; MACE = major adverse cardiovascular events; Ref. = Reference group.
a
Adjusted for age, sex, type of atrial fibrillation, hypertension, diabetes mellitus, chronic heart failure, coronary artery disease, peripheral artery disease, history of stroke/transient ischemic attack.