Table 2.
Risk of major outcomes according to the adherence to the ABC pathway in those with at least 1 comorbidity at baseline (n = 21,579).
| Outcome | Number of criteria |
0-1 vs. 2–3 criteria |
Full vs. incomplete adherence |
|||||
|---|---|---|---|---|---|---|---|---|
| 0 criteria (n = 707) (Ref.) |
1 criteria (n = 5037) aHR [95% CI]a |
2 criteria (n = 11,026) aHR [95% CI]a |
3 criteria (n = 4809) aHR [95% CI]a |
0-1 criteria (n = 5744) (Ref.) |
2-3 criteria (n = 15,835) aHR [95% CI]a |
Incomplete adherence (n = 16,770) (Ref.) |
Full adherence (n = 4809) aHR [95%CI]a |
|
| Primary outcome | ||||||||
| All-cause death and MACE | Ref. | 0.70 [0.58–0.85] | 0.59 [0.49–0.71] | 0.53 [0.43–0.65] | Ref. | 0.78 [0.72–0.86] | Ref. | 0.84 [0.75–0.94] |
| Secondary outcomes | ||||||||
| All-cause death | Ref. | 0.74 [0.59–0.92] | 0.61 [0.49–0.77] | 0.57 [0.45–0.73] | Ref. | 0.79 [0.72–0.88] | Ref. | 0.87 [0.76–0.99] |
| CV death | Ref. | 0.63 [0.45–0.89] | 0.47 [0.34–0.65] | 0.44 [0.30–0.65] | Ref. | 0.69 [0.58–0.81] | Ref. | 0.83 [0.66–1.04] |
| Stroke | Ref. | 0.72 [0.47–1.09] | 0.64 [0.42–0.96] | 0.49 [0.32–0.77] | Ref. | 0.80 [0.66–0.97] | Ref. | 0.74 [0.58–0.93] |
| Thromboembolism | Ref. | 0.75 [0.52–1.08] | 0.66 [0.46–0.94] | 0.53 [0.36–0.79] | Ref. | 0.81 [0.69–0.95] | Ref. | 0.77 [0.63–0.94] |
| MACE | Ref. | 0.65 [0.50–0.83] | 0.52 [0.41–0.66] | 0.44 [0.33–0.58] | Ref. | 0.73 [0.65–0.82] | Ref. | 0.78 [0.66–0.91] |
| Myocardial infarction | Ref. | 0.71 [0.44–1.14] | 0.58 [0.36–0.91] | 0.62 [0.37–1.03] | Ref. | 0.78 [0.62–0.99] | Ref. | 0.98 [0.72–1.32] |
| Major bleeding | Ref. | 1.00 [0.63–1.60] | 1.11 [0.71–1.75] | 1.13 [0.70–1.81] | Ref. | 1.11 [0.93–1.33] | Ref. | 1.05 [0.86–1.27] |
| All-cause death, stroke and major bleeding | Ref. | 0.78 [0.64–0.96] | 0.70 [0.57–0.85] | 0.67 [0.54–0.82] | Ref. | 0.86 [0.79–0.94] | Ref. | 0.91 [0.82–1.01] |
| All-cause death, MACE and major bleeding | Ref. | 0.76 [0.63–0.91] | 0.67 [0.56–0.81] | 0.64[0.52–0.78] | Ref. | 0.85 [0.78–0.92] | Ref. | 0.90 [0.81–0.99] |
Bold text depicts statistically significant results at p < 0.05 level.
aHR = adjusted hazard ratio; CI = confidence interval; CV = cardiovascular; MACE = major adverse cardiovascular events; Ref. = Reference group.
a
Adjusted for age, sex, type of atrial fibrillation, hypertension, diabetes mellitus, chronic heart failure, coronary artery disease, peripheral artery disease, history of stroke/transient ischemic attack.