Table 1.
Characteristics of 1′393 patients with suspected HIT included in a prospective cohort study.
| HIPA negative | HIPA positive | Overall | Missing values (n, %) | |
|---|---|---|---|---|
| N | 1274 | 119 | 1393 | |
| Age - Median (IQR) | 67.11 (57.7, 75.2) | 64.7 (55.5, 74.5) | 67.02 (57.4, 75.1) | |
| Male sex - n (%) | 816 (64.2) | 71 (59.7) | 887 (63.8) | |
| Setting - n (%) | 1 (0.1) | |||
| Post-Op general surgery or orthopedic surgery | 123 (9.7) | 9 (7.6) | 132 (9.5) | |
| Post-OP cardiovascular | 396 (31.1) | 47 (39.5) | 443 (31.8) | |
| Internal medicine | 257 (20.2) | 16 (13.4) | 273 (19.6) | |
| ICU | 479 (37.6) | 40 (33.6) | 519 (37.3) | |
| Major Trauma | 4 (0.3) | 6 (5.0) | 10 (0.7) | |
| Other | 14 (1.1) | 1 (0.8) | 15 (1.1) | |
| 4T Score - Median (IQR) | 3 (2,4) | 5 (4,6) | 4 (2,4) | 0 (0.0) |
| Thrombosis present - n (%) | 323 (25.4) | 57 (47.9) | 380 (27.3) | 0 (0.0) |
| Deep vein thrombosis | 26 (8.1) | 6 (10.5) | 32 (8.4) | |
| Pulmonary embolism | 61 (18.9) | 14 (24.6) | 75 (19.8) | |
| Other venous thromboses | 83 (2.58) | 14 (24.6) | 97 (25.6) | |
| Myocardial infarction | 11 (3.4) | 3 (5.3) | 14 (3.7) | |
| Stroke | 32 (9.9) | 6 (10.5) | 38 (10.0) | |
| Skin necrosis | 8 (2.5) | 1 (1.8) | 9 (2.4) | |
| Other arterial thromboses | 101 (31.4) | 13 (22.8) | 114 (30.1) | |
| Unfractionated heparin - n (%) | 995 (78.1) | 103 (86.6) | 1098 (78.8) | 0 (0.0) |
| Low molecular weight heparin - n (%) | 553 (43.4) | 50 (42.0) | 603 (43.3) | 0 (0.0) |
| Platelet nadir [109/L] - Median (IQR) | 60 (39, 87) | 52.00 (32, 73) | 59.00 (38, 86) | 22 (1.6) |
| CRP [mg/L] - Median (IQR) | 88 (34, 175) | 87 (44, 146) | 88 (35, 172) | 86 (6.2) |
| CLIA [U/ml] - Median (IQR) | 0 (0.0, 0.1) | 10.4 (3.8, 24.6) | 0.0 (0.0, 0.2) | 75 (5.4) |
| PaGIA [titre unit] - Median (IQR) | 0 (0, 1) | 16 (8, 64) | 0 (0, 1) | 120 (8.6) |
| ELISA [OD] - Median (IQR) | 0.1 (0.1, 0.2) | 2.5 (1.8, 3.0) | 0.1 (0.1, 0.3) | 15 (1.1) |
Abbreviations: IQR - Interquartile range, Post-op - postoperative, ICU - Intensive care unit, UFH - Unfractionated heparin, LMWH - Low-molecular-weight heparin, CRP - C-reactive protein, CLIA - chemiluminescent immunoassay, PaGIA - particle-gel immunoassay.
The heparin-induced platelet activation assay (HIPA) served as the reference standard.