Table 2.
Association between various potential predictor variables and HIPA status: results of the univariate logistic regression analysis.
| Variables | β | OR | 95% CI | p-value |
|---|---|---|---|---|
| Age | −0.01 | 0.99 | 0.98, 1.00 | 0.14 |
| Male sex | −0.20 | 0.82 | 0.56, 1.21 | 0.32 |
| Setting | ||||
| Post-op general surgery of orthopedic surgery | REF | REF | REF | REF |
| Post-op cardiovascular | 0.48 | 1.62 | 0.81, 3.62 | 0.20 |
| Internal medicine | −0.16 | 0.85 | 0.37, 2.06 | 0.71 |
| ICU | 0.13 | 1.14 | 0.56, 2.56 | 0.73 |
| Major trauma | 3.02 | 20.50 | 5.01, 94.03 | <0.01 |
| Other | −0.02 | 0.98 | 0.05, 5.79 | 0.98 |
| 4T - Score | ||||
| Degree of thrombocytopenia (per 4Ts point) | 1.08 | 2.95 | 1.98, 4.68 | <0.01 |
| Timing of thrombocytopenia (per 4Ts point) | 1.03 | 2.81 | 2.11, 3.80 | <0.01 |
| Presence of thrombosis (per 4Ts point) | 0.54 | 1.72 | 1.40, 2.10 | <0.01 |
| Possible other causes of thrombocytopenia (per 4Ts point) | 1.36 | 3.88 | 2.38, 5.37 | <0.01 |
| Type of thrombosis | ||||
| Deep vein thrombosis | REF | REF | REF | REF |
| Pulmonary embolism | −0.01 | 0.99 | 0.36, 3.07 | 0.99 |
| Other venous thromboses | −0.31 | 0.73 | 0.26, 2.24 | 0.56 |
| Myocardial infarction | 0.17 | 1.18 | 0.22, 5.39 | 0.83 |
| Skin necrosis | −0.61 | 0.54 | 0.03, 3.88 | 0.59 |
| Stroke | −0.21 | 0.81 | 0.23, 2.88 | 0.74 |
| Other arterial thromboses | −0.58 | 0.56 | 0.20, 1.71 | 0.28 |
| Clinical variables | ||||
| Chronic thrombocytopenic disorder | −0.95 | 0.39 | 0.06, 1.26 | 0.19 |
| Sepsis | −0.03 | 0.97 | 0.66, 1.41 | 0.87 |
| Chemotherapy | −1.09 | 0.34 | 0.10, 0.82 | 0.04 |
| Active cancer | −0.32 | 0.73 | 0.44, 1.15 | 0.19 |
| COVID-19 | −0.11 | 0.90 | 0.37, 1.86 | 0.79 |
| Bleedings present | −0.02 | 0.98 | 0.61, 1.51 | 0.92 |
| Therapy | ||||
| Treatment known to cause thrombocytopenia | −0.30 | 0.74 | 0.31, 1.53 | 0.46 |
| Prior heparin exposure | −0.22 | 0.80 | 0.55, 1.17 | 0.26 |
| Unfractionated heparin | 0.59 | 1.81 | 1.08, 3.22 | 0.03 |
| Low molecular weight heparin | −0.06 | 0.94 | 0.64, 1.38 | 0.77 |
| Vitamin K antagonists | −0.69 | 0.50 | 0.18, 1.14 | 0.14 |
| DOAC | 0.19 | 1.21 | 071, 1.97 | 0.46 |
| Laboratory variables | ||||
| Hemoglobin concentration (per g/L) | −0.01 | 0.99 | 0.98, 1.00 | 0.20 |
| WBC (per 109/L) | 0.02 | 1.02 | 1.01, 1.04 | <0.01 |
| C-reactive protein (per mg/L) | 0.00 | 1.00 | 1.00, 1.00 | 0.38 |
| Monocyte count (per 109/L) | 1.11 | 1.01 | 1.01, 1.21 | 0.02 |
| Platelet count at inclusion (per 109/L) | −0.01 | 0.99 | 0.99, 1.00 | <0.01 |
| Platelet nadir (per 109/L) | −0.01 | 0.99 | 0.99, 1.00 | <0.01 |
| Platelet nadir <20∗109/L | −0.72 | 0.49 | 0.15, 1.19 | 0.17 |
| Platelet peak (per 109/L) | 0.00 | 1.00 | 1.00, 1.00 | 0.02 |
| Mean platelet volume (per fL) | 0.00 | 1.00 | 0.88, 1.15 | 0.96 |
| Prothrombin time (Quick %) | 0.00 | 1.00 | 0.99, 1.00 | 0.25 |
| Immunoassays | ||||
| CLIA (per U/mL) | 0.44 | 1.56 | 1.44, 1.70 | <0.01 |
| PaGIA (titre unit) | 0.13 | 1.14 | 1.11, 1.17 | <0.01 |
| ELISA (per OD) | 2.60 | 13.41 | 9.74, 19.21 | <0.01 |
Abbreviations: OR - Odds ratio, 95% CI - 95% Confidence interval.