Table 1.

Major collagen neo-epitopes used as serum biomarkers for fibroproliferative diseases

Synthesis-related epitopes
Collagen type	Name	Description	Affected organ
Collagen type I	PINP	Amino-terminal peptide of procollagen type I	Heart
	PICP	C-terminal peptide of procollagen type I	Heart
Collagen type III	PIIINP	Amino-terminal peptide of procollagen Type III	Liver, heart, and lung
	Pro C3	A fragment of N-terminal type III collagen	Lung
Collagen type IV	P4NP7	7S domain of type IV collagen	Liver
	NC-1	Carboxy-terminal region of alpha chain	Liver
Collagen type VI	ProC6	A fragment of C-terminal type VIa3 collagen	Lung

Degradation-related epitopes
Collagen type	Name	Description	Affected organ
Collagen type I	CIM	MMP degraded fragment of Collagen type I	Lung
	CITP	Carboxy terminal telopeptide of collagen I	Heart
Collagen type III	C3M	MMP degraded fragment of Type III collagen	Liver, Lung
	C3A	ADAMTS degraded fragment of type III collagen	Lung
Collagen type IV	C4M	MMP degraded fragment of type IV collagen	Liver
Collagen type V	C5M	MMP degraded fragment of type V collagen	Lung
Collagen type VI	C6M	MMP degraded fragment of type VI collagen	Lung