Table 2.

Binding partners of galectin-3 C-terminal and N-terminal

C-terminal	Function	Reference
Bcl2	Apoptosis	Yang et al, 1996 (145)
CD95	Apoptosis	Fukumori et al, 2004 (146)
Nucling	Apoptosis	Liu et al, 2004 (147)
Alix/AIP1	Apoptosis	Liu et al, 2002 (148)
K-Ras	Cell proliferation	Eelad-sfadia et al, 2004 (149)
Akt	Cell Proliferation	Lee et al, 2003 (150), Oka et al, 2005 (151)
β-catenin	Wnt signaling	Shimura et al, 2004 (152)
Laminin	ECM adhesion	Massa et al, 1993 (153),
Fibronectin	ECM adhesion	Sato et al, 1992 (154)
Hensin	ECM adhesion	Hikita et al, 2000 (155)
Elastin	ECM adhesion	Ochieng et al, 1998 (156)
Collagen IV	ECM adhesion	Ochieng et al, 1998 (157)
Tenascin-C&-R	ECM adhesion	Probstmeier et al, 1995 (158))
α1β1 integrin	Cell adhesion	Ochieng et al, 1998 (157)
CD11b/CD18	Inflammatory macrophage	Dong et al, 1997 (28)
Lamp-1 and -2	Inflammatory macrophage	Dong et al, 1997 (28)
IgE	Inflammation	Cherayil et al, 1989 (159)
CD44	Cargo protein internalization	Lakshminarayan et al, 2014 (160)
CD98	Membrane trafficking	Dalton et al, 2007 (161)
CD66	Inflammatory neutrophils	Feuk-Lagersted et al,1999 (162)
N-terminal	Function	Reference
EGFR	Cross-linking & endocytosis	Partridge et al, 2004 (163); Liu 2012 (164)
TGFβR	Cross linking& endocytosis	Partridge et al, 2004 (163)
CD147	Clustering &MMP9 induction	Mauris et al, 2014 (138)
Alix	HIV infection	Wang et al, 2014 (139)
Alix	T cell receptor (TCR) downregulation	Chen et al, 2009 (165)
Bacterial LPS	Inflammation	Lo et al, 2021 (142)

Abbreviations: Alix, ALG2 interacting protein X; CEA, carcinoembryonic antigen.