Figure 6.
In vivo adjuvant activity of NOD2/TLR7 conjugates. NIH/OlaHsd mice (five per group) were immunized s.c. on days 0, 21, and 42 with OVA alone (10 μg) or OVA (10 μg) and the compounds (50 μg). OVA-specific IgG, IgG1, and IgG2a responses were determined 7 days after the last dose. **, p < 0.01, ***, p < 0.001 versus the control group (one-way ANOVA post hoc Dunnett’s tests).