Table 2. Preliminary Data of Thermodynamic Aqueous Solubility (μM) and Metabolic Stability (Residual Substrate %) of Selected PROTACs.

compound	PBS 0.1 M (pH = 7.4)	HCl 0.01 N (pH = 2.0)	metabolic stabilitya,b (%)
27	48	145	36
28	17	48	40
29	15	39	88
34	11	5073	60
37	8	18	89
dBET1	60c	171c	66

^aResidual substrate after 1 h incubation in MLM in the presence of NADPH.

^bThe residual substrate in control incubations without MLMs was >99%.

^cLiterature data.⁵⁸