Table 1.
Treatment protocols including CD40 alone, aPD-1 + aCTLA-4, aCD40 + aPD-1, and aCD40 + aPD-1 + aCTLA-4 (denoted CP4) were studied. Most importantly, the effect of aCD40, as determined in the lower 2 protocols, included changes in the phenotype of T cells, NK cells and DCs to mature, effector or activated phenotypes.