Table 2.

Summary table.

(Top rows) Comparing the MT4 and NDL tumor models across protocols of ablation alone, ablation + aPD-1 and aCD40 + aPD-1. Findings at 72 hours after ablation: 1) the number of genes altered by each individual treatment (for an adjusted p value < 0.05 and a fold change > 2) was greater in the NDL model compared to the MT4 model, 2) ablation created a profound wound healing response in the dense Her2⁺ breast tumors, 3) adding aCD40 to the protocol enhanced B-cell numbers in both models, 4) enhanced survival was achieved in the NDL (but not MT4) model with a simple 2-component treatment (aCD40 + aPD-1). (Bottom rows) Summary table for the MT4 model when treated with either aCD40 + aPD-1 + aCTLA-4 (denoted CP4) or ablation + CP4. Adding aCTLA4 to the treatment enhanced: 1) immune response as particularly noted in the expression of granzyme genes, 2) lymphocyte maturity or activation, as assessed by flow cytometry, 3) survival. NS = Not Significant.