Figure 4.
(A) CCR2 siRNA-encapsulated cationic nanoparticles (CNP/siCCR2) could more efficiently interrupt monocyte recruitment from peripheral blood to tumor tissues and decrease TAMs abundance, resulting in tumor microenvironment modification and tumor growth suppression. Adapted with permission from 79, copyright 2018 American Chemical Society. (B) Schematic illustration of SA/IBR/EPG nanocomplexes that increase tumor accumulation, inhibit BTK in TAMs, and exert immunotherapeutic effects. Adapted with permission from 77, copyright 2019 Elsevier Ltd. Abbreviations: siCCR2: CCR2 siRNA; CNP/siCCR2: siCCR2-encapsulated cationic nanoparticles; NNP/siCCR2: siCCR2-encapsulated neutral nanoparticles; TME: tumor microenvironment; BTK: Bruton's tyrosine kinase.