Table 1.

Genes examined for definition of cell subtypes in the IVD of rat samples (i.e., marker genes). Percentages are numbers of total cells assigned to each cluster averaged across four rats. CON—cells from control (unoperated) IVDs; LDP—cells from lumbar disc punctured IVDs at 2 or 8 weeks following surgery.

Cell Type	CON	LDP	Gene Marker
Intervertebral disc cells	2 week (87.7%) 8 week (83.7%)	2 week (82.4%) 8 week (87.4%)	Can—aggrecan Col2a1—collagen type II alpha 1 chain Sox9—SRY-box 9 Fmod—fibromodulin Comp—cartilage oligomeric matrix protein
Endothelial cells	2 week (7.3%) 8 week (0%)	2 week (6.41%) 8 week (2.3%)	Cdh5—cadherin 5 Plvap—plasmalemma vesicle-associated protein Ifitm3—interferon-induced transmembrane protein 3 Flt1—tyrosine–protein kinase receptor
Myeloid cells	2 week (1.0%) 8 week (1.2%)	2 week (1.4%) 8 week (0.8%)	Cd14—monocyte differentiation antigen CD14 Mrc1—mannose receptor C-Type 1 Cd68—CD68 antigen Lyz2—lysozyme 2
Lymphoid cells	2 week (0.2%) 8 week (8.4%)	2 week (8.2%) 8 week (5.1%)	Cd79b—B-cell antigen receptor complex-associated protein beta chain Blnk—B cell linker Ptprc—protein tyrosine phosphatase receptor type C Myb—MYB proto-oncogene, transcription factor