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EC50 values of chicken (c-) CCK-8S and CCK-4 in activating different signaling pathways of CHO cells expressing cCCK1R and cCCK2R.
| EC50 (nM) | ||
|---|---|---|
| Calcium mobilization | ||
| cCCK-8S | cCCK-4 | |
| cCCK1R | 5.41 ± 1.15 | > 100 |
| cCCK2R | 1.93 ± 0.70 | 0.91 ± 0.49 |
| MAPK/ERK signaling pathway | ||
| cCCK-8S | cCCK-4 | |
| cCCK1R | 0.32 ± 0.26 | > 100 |
| cCCK2R | 1.16 ± 0.61 | 23.88 ± 6.32 |
| cAMP/PKA signaling pathway | ||
| cCCK-8S | cCCK-4 | |
| cCCK1R | 5.76 ± 1.55 | > 100 |
| cCCK2R | 29.56 ± 7.68 | 89.66 ± 21.34 |
