| Aarhus
University Hospital (Denmark) |
Researchers discovered
that the biomarkers CD151, CD171, and tetraspanin 8 were the main dividing factors for
patients with non-small-cell lung cancer of all types versus patients
without cancer.348
|
| Craif (Japan) |
Craif developed a medical device
consisting of a zinc oxide nanowire
embedded in a microfluidic channel
that collects urinary miRNA for exosome-based liquid biopsy. They
are using machine learning technology to analyze miRNA profiles with
their original miRNA database to identify biomarkers for early cancer
detection.483
|
| Frankfurt University Hospital (Germany) |
Researchers
studied how CD81 is increased in the exosomal serum
of patients with chronic hepatitis C and appears to be associated with inflammatory activity and severity
of liver fibrosis.323
|
| Harvard Medical School (USA)/Wenzhou Medical University (China) |
Researchers have developed an incorporated tear-exosome
analysis
via rapid-isolation system (iTEARS) via nanotechnology to discover
if exosomes from tears can diagnose ocular disorders and systemic
diseases. Data show that iTEARS might be used to improve the molecular
diagnostics of dry eye disease, along with diabetic retinopathy.361 There is also a possibility that iTEARS could be used to detect other neurodegenerative
diseases and cancer. |
| Mercy Bioanalytics (USA) |
Mercy developed the Halo test for early cancer detection test
with initial focus on hard-to-treat cancers such as ovarian and lung
cancers.484 Preliminary results from studies
researching Halo detection of both early stage ovarian and lung cancers
were positive.485,486
|
| Osako
University (Japan) |
Researchers discovered that three
p53-responsive microRNAs, miR-194, miR-34a, and miR-192 are elevated in exosomes of patients with
acute myocardial infarction, suggesting that these microRNAs function
as circulating regulators of heart failure. They feel that these three
microRNAs are worth further exploration as biomarkers for ischemic
heart failure after acute myocardial infarction.487
|
| UCSF Medical Center (USA) |
Researchers discovered that levels of P-S396-tau, P-T181-tau, and Aβ1–42 from neural-derived blood exosomes can predict the development of
Alzheimer’s disease up to 10 years before clinical onset of
symptoms.306
|
| University
of Texas MD Anderson Cancer Center (USA) |
Researchers
identified a cell surface proteoglycan, glypican-1 (GPC1),
specifically enriched on cancer-cell-derived exosomes. GPC1(+) circulating exosomes may serve as a potential diagnostic and screening biomarker
for assays to detect early stages of pancreatic cancer.43
|
