| Exosomal Proteins
with respect to Their Location |
| integral transmembrane
proteins117−119
|
tetraspanins (CD81, CD82,
CD37, CD63) |
| lipid-anchored outer membrane
proteins43,120−123
|
ectonucleotidases
(CD39, CD73); sperm receptor Juno; complement-inhibiting
proteins (CD55, CD59); glypican-1; prion
proteins (PrPC, PrPSC) |
| lipid-anchored inner membrane proteins34,35,58,124−127
|
prenylated GTPases (Rabs, Ras, Rho), myristoylated
signaling
kinases (Src), palmitoylated membrane proteins, acylated Gag proteins |
| peripheral outer surface proteins128−135
|
wingless (Wnt) proteins; BMPs; TGF β; tumor necrosis factor (TNF); cytokines; extracellular
matrix (ECM)
proteins (fibronectin, tenascin C, ECM1) |
| peripheral inner membrane proteins4,102,136−142
|
scaffolding factors including the ezrin-radixin-moesin
(ERM)
proteins and ERM ligands (EBP50, CD43, CD44, IGSF8, PTGFRN); syntenin;
ALIX; heat shock proteins (HSP70, Hsp40/DnaJ proteins, Hsp90, Hsp20, Hsp27, α/β-crystallins) |
| enzymes27,120,143,144
|
ATPase,
pyruvate kinase, fatty acid synthases, phosphatases,
pyrophosphatases, calcium-binding annexins, phosphate transporters;
RNA editing enzymes, lipases, proteases, glycosyl transferases, glycosidases,
metabolic enzymes |
| cytosolic proteins117,145
|
clathrin, HSC70, HSP70, HSP60, HSP90, ALIX, YWHAE,
ubiquitin,
TSG101, ESCRT |
| Exosomal Proteins
with respect to Their Role |
| membrane transport
and fusion-related proteins |
annexin, Rab-GTPase, heat shock
proteins (HSPs), e.g., Hsp60, Hsp70,
Hsp90 |
| membrane organization and trafficking |
tetraspanins: CD9, CD63, CD81, CD82, CD106, Tspan8, ICAM-1 |
| multivesicular-body
(MVB)-related proteins |
ALIX, TSG101 |
| cell-adhesion-related proteins |
integrins |
| cytoskeletal proteins |
actin, myosin |
