Table 1.
The studies characteristics included in this meta-analysis.
| Author | Year | Region | Ethnicity | T2DM |
Control |
Matching criteria | Genotyping method | sample size (T2DM/control) | PHWE | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CG | GG | CC | CG | GG | ||||||||
| Ling Y [12] | 2011 | Shanghai | Han | 403 | 538 | 177 | 404 | 590 | 167 | Sex, ethnicity | Spectroscopy | 1118/1161 | 0.039∗ |
| Kan MY [11] | 2010 | Shanghai | Han | 585 | 960 | 367 | 675 | 989 | 350 | Sex, BMI,WHR,DBP,LDL-C,ethnicity, | PCR-RFLP | 1912/2041 | 0.707 |
| Gao KP [18] | 2016 | Guangdong | Han | 243 | 347 | 134 | 280 | 350 | 129 | Smoking, ethnicity | Taqman | 724/759 | 0.274 |
| Ronn T [10] | 2009 | Shanghai | Han | 371 | 553 | 241 | 374 | 558 | 173 | Age, sex, BMI, ethnicity | iPLEX | 1165/1105 | 0.139 |
| Shi XE [13] | 2015 | Gansu | Baoan | 80 | 100 | 44 | 144 | 208 | 52 | Age, sex, BMI,height, ethnicity | MALDI-TOF-MS | 224/404 | 0.084 |
| Liang SQ [19] | 2010 | Jilin | Han | 15 | 47 | 29 | 25 | 46 | 18 | Age, sex, DBP, TC, TG, BMI, ethnicity | PCR-RFLP | 91/89 | 0.705 |
| Tam CH [20] | 2010 | Hongkong | Han | 448 | 633 | 261 | 523 | 789 | 332 | Ethnicity | PCR-RFLP | 1342/1644 | 0.273 |
∗P < 0.05.
Abbreviations: MTNR1B: melatonin receptor 1B; T2DM: type 2 diabetes mellitus; sample size (T2DM/control) size: the total number of T2DM or control group; WHR: waist hip rate; BMI: body mass index; TC: total cholesterol; TG: triglyceride; DBP: diastolic blood pressure; PCR-RFLP: Polymerase chain reaction-restricted fragment length polymorphism; iPLEX: mult iplex PCR; MALDI-TOF-MS: Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry.