Table 2.
The current meta-analysis results under the six genetic models.
| Genetic models | Pooled OR (95% CI) | Z | P | Studies number | T2D size | control size | Pheterogeneity(I2%) |
|---|---|---|---|---|---|---|---|
| Allelic genetic model▽ | 1.038 (0.994–1.084) | 1.68 | 0.093 | 7 | 6576 | 7176 | 0.617 (0%) |
| Recessive genetic model▽ | 1.148 (1.052–1.253) | 3.10 | 0.002∗ | 7 | 6576 | 7176 | 0.061 (50.3%) |
| Dominant genetic model▽ | 0.950 (0.885–1.020) | 1.41 | 0.160 | 7 | 6576 | 7176 | 0.154 (35.9%) |
| Heterozygous genetic model▽ | 1.016 (0.943–1.096) | 0.42 | 0.672 | 7 | 6576 | 7176 | 0.264 (21.7%) |
| Homozygous genetic model△ | 1.197 (1.023–1.401) | 2.24 | 0.025∗ | 7 | 6576 | 7176 | 0.045∗ (53.4%) |
| Additive genetic model▽ | 1.067 (1.017–1.120) | 2.65 | 0.008∗ | 7 | 6576 | 7176 | 0.063 (49.9%) |
∗P < 0.05.
▽: the “fixed effects model” was applied to compute the pooled OR under the allelic, recessive, dominant, heterozygous and additive genetic models.
△: the “random effects model” was applied to compute the pooled OR under the homozygous genetic models.
Abbreviations: CI: confidence interval; OR: odds ratio; T2D size: the total number of T2DM cases; control size: the total number of control group; Allelic genetic model: G allele vs. G allele + C allele; Recessive genetic model: GG vs. CC + CG; Dominant genetic model: CC vs. GG + CG; Heterozygous genetic model: CG vs. CC; Homozygous genetic model: GG vs. CC; Additive genetic model: G allele vs. C allele.