Table 4. Cox proportional hazards regression model to predict a MACE.
| Univariate analysis | Multivariate analysis model 1 | Multivariate analysis model 2 | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age | 1.05 (1.02-1.08) | <0.001 | 1.05 (1.02-1.09) | <0.001 | 1.07 (1.02-1.11) | <0.001 |
| Male | 0.71 (0.31-1.58) | 0.4 | – | – | – | – |
| Diabetes | 1.28 (0.63-2.62) | 0.48 | – | – | – | – |
| Current smoking habits | 0.91 (0.46-1.73) | 0.79 | – | – | – | – |
| Previous PCI | 2.41 (0.84-6.88) | 0.1 | – | – | – | – |
| Killip class II or more | 1.40 (0.92-2.13) | 0.1 | – | – | – | – |
| Baseline TIMI flow 0 or 1 | 1.08 (0.75-1.57) | 0.65 | – | – | – | – |
| Creatinine level | 1.05 (0.20-5.32) | 0.94 | – | – | – | – |
| Haemoglobin level | 1.00 (0.84-1.20) | 0.93 | – | – | – | – |
| BNP level | 1.00 (0.00-1.00) | 0.13 | – | – | – | – |
| Peak CK-MB level | 1.00 (0.99-1.00) | 0.19 | – | – | – | – |
| Use of IABP | 4.33 (1.50-12.4) | <0.01 | 7.90 (2.60-24.0) | <0.001 | 4.28 (1.35-13.57) | 0.01 |
| Onset-to-balloon time | 1.02 (0.90-1.15) | 0.72 | – | – | – | – |
| LAD culprit | 1.79 (0.88-3.66) | 0.1 | – | – | – | – |
| LVEDP | 1.11 (1.06-1.17) | <0.001 | – | – | 1.13 (1.06-1.20) | <0.001 |
| LVEF | 0.96 (0.93-0.99) | 0.02 | 0.96 (0.94-0.99) | 0.02 | 0.99 (0.96-1.02) | 0.74 |
| GRACE score | 1.01 (1.00-1.02) | 0.003 | 1.00 (0.99-1.01) | 0.64 | 1.00 (0.98-1.01) | 0.79 |
| BNP: brain natriuretic peptide; CI: confidence interval; CK-MB: creatinine kinase-myocardial band; GRACE: Global Registry of Acute Coronary Events; HR: hazard ratio; IABP: intra-aortic balloon pump; LAD: left anterior descending artery; LVEDP: left ventricular end-diastolic pressure; LVEF: left ventricular ejection fraction; MACE: major adverse cardiac event; PCI: percutaneous coronary intervention; TIMI: Thrombolysis In Myocardial Infarction | ||||||