Table 4.
Results from the Principal Component Analyses including MTX initiators
| Contribution of individual cell type to the component (%) | Coefficients with correlation between cells type and components | |||||||
|---|---|---|---|---|---|---|---|---|
| Component | Component | |||||||
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | |
| Tc cells | 4.05 | 13.03 | 3.16 | 47.33 | 0.33 | 0.51 | -0.22 | 0.69 |
| Th1 cells | 0.03 | 32.06 | 5.12 | 0.01 | -0.03 | 0.80 | 0.28 | 0.01 |
| Th17 cells | 16.44 | 13.53 | 0.57 | 8.33 | -0.66 | 0.52 | 0.09 | -0.29 |
| nTregs | 4.04 | 10.89 | 32.60 | 0.31 | -0.32 | -0.46 | 0.71 | 0.06 |
| amTregs | 29.69 | 0.93 | 0.41 | 5.37 | -0.88 | -0.14 | 0.08 | 0.23 |
| umTregs | 21.94 | 1.93 | 2.11 | 20.86 | -0.76 | 0.20 | 0.18 | 0.46 |
| Dendritic cells | 18.77 | 0.04 | 9.71 | 7.91 | -0.70 | 0.03 | -0.39 | -0.28 |
| NK cells | 0.05 | 26.00 | 0.71 | 9.17 | -0.04 | 0.72 | 0.01 | -0.30 |
| Monocytes | 5.00 | 1.60 | 46.33 | 0.71 | -0.36 | -0.18 | -0.18 | 0.08 |
Important contribution to the component was defined as contribution above the average ~11.1%. Correlation coefficients >0.50 were considered strong. Bold text represents values of important contribution and strong correlation coefficients, respectively
MTX methotrexate, Tc CD8+ cytotoxic T cells, Th1 T helper cell type 1, Th17 T helper cell type 17, nTregs naïve T regulatory cells, amTregs activated memory T regulatory cells, umTregs unactivated memory T regulatory cells, NK cells natural killer cells