Fig. 1.

Flow diagram of CANVAS subset used for the current analysis. The subset of CANVAS used in the current analysis consisted of patients that agreed to samples being used for research (n = 3531). Of the 3531 patients who gave permission, baseline plasma samples were available for 3531 patients (1178 placebo/2353 CANA) and baseline urine samples were available for 3447 patients (1147 placebo/2300 CANA). At year 3, plasma samples were available for 2178 patients (682 placebo/1496 CANA), and urine samples were available for 2128 (655 placebo/1473 CANA). The discrepancy in number between plasma and urine samples was due to missing samples