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Survival of hamsters challenged with L. kirschneri after immunization with leptospiral OMPs. Hamsters were immunized with E. coli membrane fractions with and without OmpL1-M, LipL41-M, or a combination of both. Bars denote percent survival at various time points after i.p. challenge with virulent L. kirschneri. Asterisks denote a significant difference in survival versus control (P < 0.05). Data represent the sum of three separate experiments.
