TABLE 2.
Protective effect of immunization with a combination of OmpL1-M and LipL41-M
| Group | No. (%) of surviving
animals/groupa
|
|||
|---|---|---|---|---|
| Expt 1 | Expt 2 | Expt 3 | Total | |
| OmpL1-M | 9/9 (100) | 0/6 (0) | 1/9 (11) | 10/24 (42) |
| Control | 3/9 (33) | 0/6 (0) | 3/15 (20) | |
| Significance | P < 0.004 | NS | NSb | NS |
| LipL41-M | 2/7 (29) | 1/6 (17) | 2/9 (22) | 5/22 (23) |
| Control | 3/9 (33) | 0/6 (0) | 3/15 (20) | |
| Significance | NS | NS | NSb | NS |
| OmpL1-M + LipL41-M | 9/9 (100) | 3/6 (50) | 5/9 (55) | 17/24 (71) |
| Control | 3/9 (33) | 1/6 (17) | 2/9 (22) | 6/24 (25) |
| Significance | P < 0.004 | NS | NS | P < 0.001 |
a
Number of surviving animals at 28 days after challenge/number of animals challenged. Statistical analysis was performed by using Student's t test for two independent means (significance, P < 0.05). NS, not significant.
b
Significance determined by comparison to control group for OmpL1-M + LipL41-M arm of experiment 3.