Table 2.
The effect of nagZ on MICs for six anbiotics
| Antibiotics | MIC(μg/ml) | ||||||
|---|---|---|---|---|---|---|---|
| WT | ΔnagZ |
ΔnagZ + CFZ (4 μg/ml) |
ΔnagZ + IMP (0.0625 μg/ml) |
ΔnagZ + NagZ |
ΔnagZ + NagZ + CFZ(256 μg/ml) |
ΔnagZ + NagZ + IMP(0.125 μg/ml) |
|
| PIP | 64 | 2 | 2 | 1 | 32 | 256 | 512 |
| TZP | 32 | 2 | 1 | 0.5 | 32 | 128 | 512 |
| ATM | 32 | 1 | 1 | 0.5 | 16 | 256 | 512 |
| CRO | 16 | 0.5 | 0.5 | 0.25 | 32 | 64 | 1024 |
| CAZ | 16 | 0.5 | 0.5 | 0.25 | 16 | 64 | 128 |
| SCF | 4 | 0.25 | 0.125 | 0.0625 | 4 | 64 | 64 |
Abbreviations: ΔnagZ nagZ-knockout Enterobacter cloacae complex, ΔnagZ + CFZ ΔnagZ treated with CFZ, ΔnagZ + IMP ΔnagZ treated with IMP, ΔnagZ + NagZ + CFZ ΔnagZ + NagZ treated with CFZ, ΔnagZ + NagZ + IMP ΔnagZ + NagZ treated with IMP