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. 2022 Nov 29;22:884. doi: 10.1186/s12884-022-05205-w

Table 2.

Generalized linear model of blood loss after vaginal birth by OXTR genotype (rs53576) accounting for relevant covariates

Total blood loss volume
β(95%CI)
Model 1
 OXTR A/G & A/A (vs. GG) 203.78 (6.01 – 401.54)*
 European Ancestry vs. None 40.77 (-219.51 – 301.07)
Model 2
  OXTR A/G & A/A (vs. GG) 300.76 (126.61 – 474.92)***
  European Ancestry vs. None 110.21 (-112.84 – 333.27)
  Oxytocin dosage during labor (per Unit) 24.20 (7.64 – 40.76)**
Model 3
  OXTR A/G & A/A (vs. GG) 275.24 (96.33 – 454.16)**
  European Ancestry vs. None 147.18 (-79.13 – 373.49)
  Oxytocin dosage during labor (per Unit) 20.85 (3.64 – 38.07)*
  Primiparity 125.77 (-68.33 – 319.88)
Model 4
  OXTR A/G & A/A (vs. GG) 278.09 (100.36 – 455.83)**
  European Ancestry vs. None 133.36 (-94.05 – 360.77)
  Oxytocin dosage during labor (per Unit) 20.68 (-3.08 – 38.28)*
  Primiparity 95.89 (-124.97 – 316.76)
  Genital tract lacerations 29.46 (-55.09 – 127.26)
Model 5
  OXTR A/G & A/A (vs. GG) 275.16 (96.92 – 453.40)**
  European Ancestry vs. None 148.99 (-75.19 – 373.18)
  Oxytocin dosage during labor (per Unit) 21.25 (3.74 – 38.75)*
  Primiparity 21.25 (3.74 – 38.75)*
  Active Management of Third Stage Labor -33.04 (-259.81 – 193.72)

*models including Latin American ancestry as a covariate were not materially different than controlling for only European ancestry