Table 3.
Toxicities between two groups
| Toxicity (No.) | IC+ CCRT group (n = 53) |
CCRT group (n = 60) |
P value†† | ||
|---|---|---|---|---|---|
| Grade 1-2 | Grade 3-4 | Grade 1-2 | Grade 3-4 | ||
| Hematologicala | 18 (34.0) | 29 (54.7) | 43 (71.7) | 6 (10.0) | < 0.001 |
| Leukopenia | 24 (45.3) | 22 (41.5) | 43 (71.7) | 4 (6.7) | < 0.001 |
| Neutropenia | 13 (24.5) | 27 (50.9) | 21 (35.0) | 4 (6.7) | < 0.001 |
| Anemia | 19 (35.8) | 0 (0) | 14 (23.3) | 0 (0) | 0.154 |
| Thrombocytopenia | 15 (28.3) | 1 (1.9) | 15 (25.0) | 0 (0) | 0.509 |
| Hematological (IC)b | 14 (26.4) | 27 (50.9) | NA | NA | NA |
| Leukopenia | 18 (34.0) | 20 (37.7) | NA | NA | NA |
| Neutopenia | 10 (18.9) | 26 (49.1) | NA | NA | NA |
| Anemia | 6 (11.3) | 0 (0) | NA | NA | NA |
| Thrombocytopenia | 8 (15.1) | 1 (1.9) | NA | NA | NA |
| Hematological (CCRT)c | 35 (66.0) | 5 (9.4) | 43 (71.7) | 5 (8.3) | 0.807 |
| Leukopenia | 35 (66.0) | 4 (7.5) | 42 (70.0) | 4 (6.7) | 0.903 |
| Neutopenia | 16 (30.2) | 2 (3.8) | 21 (35.0) | 3 (5.0) | 0.795 |
| Anemia | 17 (32.1) | 0 (0) | 14 (23.3) | 0 (0) | 0.398 |
| Thrombocytopenia | 10 (18.9) | 1 (1.9) | 15 (25.0) | 0 (0) | 0.433 |
| Non-Hematological | |||||
| Skin | 46 (86.8) | 4 (7.5) | 51 (85.0) | 8 (13.3) | 0.339 |
| Mucositis | 41 (77.4) | 8 (15.1) | 48 (80.0) | 11 (18.3) | 0.301 |
| Xerostomia | 43 (81.1) | 0 (0) | 48 (80.0) | 0 (0) | 1.000 |
| Odynophagia | 41 (77.4) | 7 (13.2) | 46 (76.7) | 7 (11.7) | 0.910 |
| Renal function | 5 (9.4) | 0 (0) | 0 (0) | 0 (0) | 0.020 |
| Liver function | 1 (1.9) | 0 (0) | 2 (3.3) | 0 (0) | 1.000 |
Data are No. (%) unless otherwise indicated
Abbreviations: CCRT chemoradiotherapy, IC induction chemotherapy
††P value: P value of Grade 3-4 between the two groups
aHematological: toxicities were evaluated during the whole treatment
bHematological (IC): toxicities were evaluated during the induction chemotherapy
cHematological (CCRT): toxicities were evaluated during the chemoradiotherapy