Table 3.

Improvement in risk prediction by adding TYG index to risk factors and clinical models

	NRI [95% CI]	P value	IDI [95% CI]	P value	Δ in C-statistics	P value
5-year worsening HF
ProBNP	0.19 (0.03–0.29)	< 0.001	0.02 (0.01–0.06)	< 0.001	0.01	< 0.001
LVEF	0.21 (0.06–0.31)	0.01	0.02 (0.00–0.05)	0.01	0.05	< 0.001
hs-cTnT	0.19 (0.01–0.28)	0.01	0.02 (0.01–0.05)	< 0.001	0.03	< 0.001
MUSIC Risk score	0.24 (0.06–0.33)	< 0.001	0.03 (0.00–0.06)	< 0.001	0.03	< 0.001
5-year MACE
ProBNP	0.09 (− 0.03–0.18)	0.09	0.01 (0.00–0.03)	0.03	0.01	0.03
LVEF	0.07 (− 0.03–0.16)	0.189	0.01 (0.00–0.02)	0.06	0.02	0.03
hs-cTnT	0.05 (− 0.05–0.16)	0.289	0.01 (0.00–0.03)	0.109	0.04	0.04
GRACE score in ACS	0.06 (− 0.06–0.17)	0.299	0.01 (− 0.00–0.03)	0.100	0.00	0.105

Δ difference, IDI integrated discrimination improvement, NRI net reclassification index