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. 2022 Nov 29;309:104000. doi: 10.1016/j.resp.2022.104000

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Fig. 6 — Ventilation/ perfusion alteration in AIP, ARDS, HAPE, and COVID-19. This figure depicts ventilation (V’)/ perfusion (Q’) changes in five possible conditions. 1) AIP characterized mainly by wasted ventilation and true shunt due to alveolar consolidation with less low V’/Q’; 2) ARDS characterized mainly by mainly wasted ventilation and less low V’/Q’, with high true shunt due to alveolar collapse, and the perfusion follow a gravitational gradient; 3) HEPA characterized by wasted ventilation and less low V’/Q’, with high true shunt due to alveolar collapse; 4) COVID-19 phenotype 1 characterized by wasted ventilation and low V’/Q’ and less true shunt due to alveolar consolidation but perfusion follow an antigravitational gradient; and 5) COVID-19 phenotype 2 characterized by wasted ventilation and low V’/Q’ and higher true shunt mainly due to consolidation, and the perfusion follow an antigravitational gradient.