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PP2A is a family of heterotrimeric complexes that regulates many different cellular processes that are crucial for oncogenic transformation. PP2A is composed of a catalytic subunit (PP2A C) and a scaffolding subunit (PP2A A) with two isoforms (α and β) and various substrate-directing B regulatory subunits. The different families of B regulatory subunits, which can be further subsetted by their respective isoforms (3, 5, 11, 12, 13).
