Figure 3.

PP2A Aα mutants effect the PP2A interactome in a graded manner.A, the different cancer-associated PP2A Aα mutants can be broken down by the degree to which they lose binding to PP2A Cα/β. B, similarly, the mutants can be broken down by the degree to which they lose binding to the B55 and B56 family members. Collectively, this illustrates that the scaffold mutants that demonstrate loss of catalytic subunit often demonstrate coordinate loss of association with the more tumor-suppressive B regulatory subunits (39, 46, 47, 55, 63, 64, 65, 66, 67). Recurrent PPP2R1A hotspot mutations with greater than ten independent observations in cancer were bolded to demonstrate the effect on PP2A heterotrimer formation (69).