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PP2A is a family of serine/threonine phosphatases composed of the PP2A Aα scaffolding subunit, the PP2A Cα catalytic subunit, and over 20 different regulatory subunits that display differing sensitivities to carbomethylation of the catalytic subunit. The mechanism of dysregulation of each class of subunits in cancer is illustrated in the figure as well as therapeutic intervention being developed as disease-modifying therapies.
