Table 1.
Characteristics of patients with RA enrolled in the MGB Biobank by MUC5B promoter variant genotype (n = 1005)
| Characteristics | MUC5B TT genotype (n = 10) | MUC5B GT genotype (n = 145) | MUC5B GG genotype (n = 850) | P-value |
|---|---|---|---|---|
| Demographics | ||||
| Sex, female, n (%) | 8 (80) | 111 (76.6) | 676 (79.5) | 0.71 |
| European ancestry, n (%) | 9 (90) | 135 (93.1) | 666 (78.4) | <0.0001 |
| Smoking status, n (%) | 0.21 | |||
| Never | 5 (50) | 62 (42.8) | 445 (52.4) | |
| Past | 4 (40) | 68 (46.9) | 342 (40.2) | |
| Current | 1 (10) | 15 (10.3) | 63 (7.4) | |
| Smoking pack-years, median (IQR) | 0.13 (0–15.8) | 2.5 (0–17.5) | 0 (0–10) | 0.09 |
| RA clinical features | ||||
| Age at RA diagnosis, years, median (IQR) | 59.5 (53.8–66.2) | 48.0 (36.1–58.8) | 45.7 (32.9–56.6) | 0.03 |
| RA diagnosis at age >55 years, n (%) | 6 (60) | 55 (37.9) | 242 (28.5) | 0.008 |
| Seropositive RA, n (%) | 5 (50) | 80 (55.2) | 520 (61.2) | 0.40 |
| RF status, n (%) | 0.13 | |||
| Positive | 5 (50) | 64 (44.1) | 463 (54.5) | |
| Negative | 4 (40) | 73 (50.3) | 340 (40.0) | |
| Missing | 1 (10) | 8 (5.5) | 47 (5.5) | |
| Anti-CCP status, n (%) | 0.76 | |||
| Positive | 4 (40) | 48 (40) | 376 (44.2) | |
| Negative | 4 (40) | 67 (46.2) | 348 (40.9) | |
| Missing | 2 (20) | 20 (13.8) | 126 (14.8) | |
| Shared epitope present, n (%) | 4 (40) | 71 (49.0) | 375 (44.1) | 0.34 |
| RA-GRS, median (IQR) | 11.7 (10.7–12.1) | 12.1 (10.5–13.6) | 12.1 (10.7–13.4) | 0.43 |
| RA-ILD, n (%) | 3 (30) | 17 (11.7) | 32 (3.8) | <0.0001 |
| UIP pattern | 2 (20.0) | 6 (4.1) | 9 (1.1) | 0.0006 |
| Fibrotic NSIP pattern | 0 (0) | 5 (3.5) | 6 (0.7) | 0.02 |
| Other ILD | 0 (0) | 2 (1.4) | 9 (1.1) | 0.70 |
| Unknown/unclassified ILD | 1 (10) | 4 (2.8) | 8 (0.9) | 0.02 |
NSIP: non-specific interstitial pneumonia; UIP: usual interstitial pneumonia; GRS: genetic risk score. Bold denotes results that had P-value < 0.05.