Table 2.
Associations of the MUC5B promoter variant with RA and RA-ILD characteristics
| Outcomes | MUC5B promoter variant (GT or TT genotype) (n = 155) | No MUC5B promoter variant (n = 850) |
|---|---|---|
| RA-ILD, n (%) | 20 (12.9) | 32 (3.8) |
| Unadjusted ORa (95% CI) | 3.36 (2.02, 5.47) | Ref |
| Adjusted ORa,b (95% CI) | 3.34 (1.97, 5.60) | Ref |
| RA-ILD before or within 2 years of RA diagnosis, n (%) | 9 (5.8) | 7 (0.8) |
| Unadjusted ORa (95% CI) | 4.91 (2.23, 10.40) | Ref |
| Adjusted ORa,b (95% CI) | 4.01 (1.78, 8.80) | Ref |
| RA diagnosis at age >55 years, n (%) | 61 (39.4) | 242 (28.5) |
| Unadjusted ORa (95% CI) | 1.62 (1.18, 2.24) | Ref |
| Adjusted ORa,c (95% CI) | 1.52 (1.08, 2.12) | Ref |
a
OR per copy of rs35705950 G>T [GG genotype has zero copies (reference group), GT genotype has one copy, TT genotype has two copies].
b
Adjusted for age at RA diagnosis, sex, genetic ancestry, RA-GRS, smoking and continuous smoking pack-years.
c
Adjusted for sex, genetic ancestry, RA-GRS, smoking and continuous smoking pack-years. Bold results have statistically significant odds ratios that do not include 1.0.