Table 3.
Associations of the MUC5B promoter variant with RA and RA-ILD characteristics stratified by sex
| Outcomes | Female (n = 795) |
Male (n = 210) |
P for interaction | ||
|---|---|---|---|---|---|
| MUC5B promoter variant GT or TT genotype (n = 119) | No MUC5B promoter variant (n = 676) | MUC5B promoter variant GT or TT genotype (n = 36) | No MUC5B promoter variant (n = 174) | ||
| RA-ILD, n (%) | 13 (10.9) | 21 (3.1) | 7 (19.4) | 11 (6.3) | |
| Unadjusted ORa (95% CI) | 3.34 (1.79, 5.99) | 1.00 (ref) | 3.39 (1.33, 8.37) | 1.00 (ref) | 0.98 |
| Adjusted ORa,b (95% CI) | 3.31 (1.72, 6.17) | 1.00 (ref) | 4.13 (1.51, 11.34) | 1.00 (ref) | 0.82 |
| RA-ILD before or within 2 years of RA diagnosis, n (%) | 5 (4.2) | 4 (0.6) | 4 (11.1) | 3 (1.7) | |
| Unadjusted ORa (95% CI) | 4.13 (1.36, 10.94) | 1.00 (ref) | 6.57 (1.84, 25.35) | 1.00 (ref) | 0.57 |
| Adjusted ORa,b (95% CI) | 3.52 (1.13, 9.93) | 1.00 (ref) | 9.20 (2.19, 46.68) | 1.00 (ref) | 0.40 |
| RA diagnosis at age >55 years, n (%) | 45 (37.8) | 165 (24.4) | 16 (44.4) | 77 (44.3) | |
| Unadjusted ORa (95% CI) | 1.80 (1.24, 2.60) | 1.00 (ref) | 1.14 (0.58, 2.23) | 1.00 (ref) | 0.24 |
| Adjusted ORa,c (95% CI) | 1.67 (1.13, 2.46) | 1.00 (ref) | 1.11 (0.55, 2.20) | 1.00 (ref) | 0.35 |
a
OR per copy of rs35705950 G>T [GG genotype has zero copies (reference group), GT genotype has one copy, TT genotype has two copies].
b
Adjusted for age at RA diagnosis, sex, genetic ancestry, RA-GRS, smoking and continuous smoking pack-years.
c
Adjusted for sex, genetic ancestry, RA-GRS, smoking and continuous smoking pack-years. Bold results have statistically significant odds ratios that do not include 1.0.