Table 1.

VMAP Cohort Demographics

Characteristic	Clinical Diagnosis		Total (N=155)	P-value
	Normal Cognition (N=83)	Mild Cognitive Impairment (N=72)
Male, no. (%)	58 (70)	46 (63)	104 (67)	0.535
Age (baseline)	72±6.50	72±6.18	72±6.33	0.458
Education	17±2.41	15±2.94	16±2.80	0.001
APOE-ε4 carriers, no. (%)	24 (29)	27 (38)	51 (33)	0.334
sTREM2 CSF pg/mL	3530±1867.29	3817±1759.49	3667±1812.50	0.327
p-tau181 CSF pg/mL (% p-tau positive) †	56±21.92(17)	67±28.59(26)	61±25.70(21)	0.212
Aβ1-42 CSF pg/mL (% Aβ positive) ††	760±229.54 (20)	662±254.02 (40)	714±245.40 (30)	0.012

Values are presented as mean±standard deviation, unless otherwise indicated. A student’s t-test or a Pearson’s chi-squared test was used to compare continuous or categorical variables, respectively, between cognitive diagnoses. Bold represents statistical significance set to a priori threshold P<0.05. 6 participants are Black/African American; 2 American Indian/Alaska Native; 2 Asian.

^†p-tau positive ≥ 80pg/mL

^††Aβ positive ≤ 530pg/mL.