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. Author manuscript; available in PMC: 2023 May 7.
Published in final edited form as: Nat Struct Mol Biol. 2022 Nov 7;29(11):1122–1135. doi: 10.1038/s41594-022-00856-x

Fig. 2: The CoREST complex is essential for endocrine sensitive and resistant breast cancer cell proliferation and survival.

Fig. 2:

a, Impaired proliferation of parental and reprogrammed LSD1 KO and primed siLSD1 T47D, n = 3. n = 3 biological independent replicates. Data are presented as mean values + SEM. Significance determined by two-way ANOVA, p-value < 0.05. b, Clonogenic assay of parental and reprogrammed LSD1 KO cells. c, Volcano plots of DEGs (FC > 1.5, adjusted p-value < 0.05). d, GSEA suggests a downregulation of metastatic potential and estrogen response following LSD1 loss. e, Significant LSD1 interactions assayed by endogenous immunoprecipitation followed by LC-MS/MS (orange = LSD1/CoREST subunits, blue = other known LSD1 interactors, red = BAF subunits), n = 3 biological independent replicates. f, GSK-LSD1 and corin IC50 curves, n = 3 biological independent replicates. GSK-LSD1 exhibited no inhibitory activity. Corin IC50 values: parental = 1.191µM, primed = 0.6877µM, reprogrammed = 1.071µM. Data are presented as mean values + SEM.