Skip to main content
. 2021 Mar 5;13(1):56–76. doi: 10.1080/21541248.2021.1892443

Figure 6.

Figure 6.

A putative model of the C9orf72-RAB complex.

a. The structure model of C9orf72 (PDB: 6LT0), Longin domain: orange, DENN domain: blue.

b. DENND1B-RAB35 (PDB: 3TW8), Longin domain: green, DENN domain: red, RAB35: grey.

c. Superimposition of the structure models of C9orf72 and DENND1B-RAB35. The colours are same as (A) and (B). The two structures will adopt a similar overall structure after that the DENN domain of C9orf72 rotates ~90° and moves ~45 Å towards the DENN of DENND1B.

d. The structure model of C9orf72 adopts similar folds to DENND1B.

e. The putative structure model of C9orf72-RAB is generated on the basis of the structure of DENND1B-RAB35.