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. 2021 Mar 5;13(1):56–76. doi: 10.1080/21541248.2021.1892443

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Figure 9. — A putative model of the C9orf72-SMCR8-RAB complex.

a. The structure of the C9orf72-SMCR8 complex (PDB: 6LT0), Longin domain: orange (C9orf72), and pink (SMCR8), DENN domain: blue (C9orf72) and cyan (SMCR8).

b. The structure of the MON1-CCZ1-RAB7 complex (PDB: 5LDD). MON1-Longin: wheat, CCZ1-Longin: pale green, RAB7: grey.

c. And d. Superimposition of C9orf72-SMCR8 complex and MON1-CCZ1-RAB7 complex. The two Longin pairs will adopt a similar overall structure after the SMCR8-Longin moves ~20 Å towards the RAB7.

e. The putative structure model of the C9orf72-SMCR8-RAB complex.