Table 1.
Clinical characteristics of the patients with anti-NMDAR encephalitis and healthy controls.
| Clinical characteristics |
Anti-NMDAR encephalitis
(n = 161) |
Control
(n = 178) |
p |
|---|---|---|---|
| Age, years, median (IQR) | 25 (16–37) | 27 (17–39.25) | 0.623 |
| Gender, female, n (%) | 73 (45.34) | 85 (47.75) | 0.657 |
| Hypertension, n (%) | 14 (8.70) | 11 (6.18) | 0.376 |
| Diabetes, n (%) | 4 (2.48) | 3 (1.68) | 0.605 |
| PT, median (IQR; s) | 11.0 (10.2–11.6) | 10.5 (10.1–11.1) | <0.001* |
| APTT, median (IQR; s) | 28.8 (26.05–31.45) | 32.1 (29.68–34.50) | <0.001* |
| Fibrinogen, median (IQR; g/L) | 2.78 (2.32–3.35) | 2.45 (2.17–2.89) | <0.001* |
| TT, median (IQR; s) | 14.60 (13.45–16.00) | 14.95 (14.18–16.03) | 0.021* |
| D-dimer, median (IQR; mg/L) | 0.14 (0.07–0.36) | 0.05 (0.038–0.08) | <0.001* |
| WBC, median (IQR; 109/L) | 8.54 (6.60–11.60) | 5.95 (4.96–6.90) | <0.001* |
| RBC, mean ± SD (1012/L) | 4.34 ± 0.53 | 4.53 ± 0.48 | 0.001* |
| Hemoglobin, mean ± SD (g/L) | 130.20 ± 16.55 | 135.37 ± 15.00 | 0.001* |
| Platelet, median (IQR; 109/L) | 240 (197–308) | 233 (190.75–282.25) | 0.15 |
| Neutrophil, median (IQR; 109/L) | 6.14 (3.96–8.91) | 3.10 (2.55–4.00) | <0.001* |
| Lymphocyte, median (IQR; 109/L) | 1.56 (1.13–2.46) | 2.02 (1.65–2.46) | <0.001* |
| Monocytes, median (IQR; 109/L) | 0.56 (0.43–0.75) | 0.41 (0.35–0.51) | <0.001* |
| Eosinophils, median (IQR; 109/L) | 0.04 (0.01–0.10) | 0.11 (0.07–0.18) | <0.001* |
| Basophil, median (IQR; 109/L) | 0.03 (0.01–0.04) | 0.03 (0.02–0.04) | 0.026* |
Normally distributed variables were presented as mean ± SD and compared using t-tests. Non-normally distributed variables were presented as median (IQR = 25–75th percentile) and were contrasted using the Mann-Whitney U-test. Categorical variables were described as number (percentage), and the chi-square test or Fisher's exact test was used for comparison between groups.
Anti-NMDAR encephalitis, anti-N-methyl-D-aspartate receptor encephalitis; PT, prothrombin time; APTT, activated partial thrombin time; TT, thrombin time; WBC, white blood cell; RBC, red blood cell.
*
p < 0.05.