TABLE 5.
Proteomic differences in mouse muscle tissues: Ketone ester (KE) vs. control diets 33 proteins were significantly lower in KE compared to CON.
| Statistics |
||||||||
| UniProtKB names | Gene name | Prot Acc# | GeneID | Avg (C) | Avg (KE) | P | SAM | Fold (KE/C) |
| Serine protease inhibitor A3K | serine (or cysteine) peptidase inhibitor, clade A, member 3K (Serpina3k) | P07759 | 20714 | 8.1 | 2.5 | 0.022 | 0.81 | −3.27 |
| Serine/threonine-protein phosphatase 2B | protein phosphatase 3, catalytic subunit, alpha isoform (Ppp3ca) | P63328 | 19055 | 3.8 | 1.3 | 0.017 | 0.88 | −2.82 |
| 10 kDa heat shock protein | heat shock protein 1 (chaperonin 10) (Hspe1) | Q64433 | 15528 | 4.6 | 1.7 | 0.020 | 1.00 | −2.66 |
| Annexin A1 | annexin A1 (Anxa1) | P10107 | 16952 | 5.1 | 2.0 | 0.029 | 0.84 | −2.58 |
| Alpha-2-macroglobulin | pregnancy zone protein (Pzp) | Q61838 | 11287 | 23.9 | 9.9 | 0.003 | 0.98 | −2.40 |
| Acyl-coenzyme A thioesterase 13 | acyl-CoA thioesterase 13 (Acot13) | Q9CQR4 | 66834 | 8.6 | 3.8 | 0.041 | 0.53 | −2.24 |
| ES1 protein homolog, mitochondrial | DNA segment, Chr 10, Johns Hopkins University 81 expressed (D10Jhu81e) | Q9D172 | 28295 | 13.5 | 6.2 | 0.001 | 1.14 | −2.15 |
| Murinoglobulin-1 | murinoglobulin 1 (Mug1) | P28665 | 17836 | 20.6 | 9.7 | 0.002 | 1.13 | −2.13 |
| Transgelin | transgelin (Tagln) | P37804 | 21345 | 5.1 | 2.4 | 0.043 | 0.58 | −2.12 |
| Gelsolin, isoform CRA_c | gelsolin (Gsn) | Q6PAC1 | 227753 | 3.9 | 1.9 | 0.016 | 0.74 | −2.08 |
| Dual specificity protein phosphatase 3 | dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3) | Q9D7 × 3 | 72349 | 8.1 | 3.9 | 0.004 | 1.01 | −2.07 |
| S-formylglutathione hydrolase | esterase D/formylglutathione hydrolase (Esd) | Q9R0P3 | 13885 | 2.7 | 1.3 | 0.010 | 1.05 | −2.02 |
| Vesicle-associated membrane protein | vesicle-associated membrane protein, associated protein A (Vapa) | Q9WV55 | 30960 | 6.5 | 3.3 | 0.030 | 0.67 | −1.98 |
| Galectin-1 | lectin, galactose binding, soluble 1 (Lgals1) | P16045 | 16852 | 10.6 | 5.4 | 0.002 | 1.15 | −1.98 |
| Endoplasmin | heat shock protein 90, beta (Grp94), member 1 (Hsp90b1) | P08113 | 22027 | 5.7 | 3.0 | 0.007 | 0.89 | −1.90 |
| Glutathione S-transferase kappa 1 | glutathione S-transferase kappa 1 (Gstk1) | Q9DCM2 | 76263 | 3.4 | 1.8 | 0.021 | 0.88 | −1.84 |
| 6-phosphogluconolactonase | 6-phosphogluconolactonase (Pgls) | Q9CQ60 | 66171 | 4.2 | 2.3 | 0.015 | 0.84 | −1.83 |
| Thioredoxin reductase 1 | thioredoxin reductase 1 (Txnrd1) | Q9JMH6 | 50493 | 3.8 | 2.1 | 0.041 | 0.64 | −1.82 |
| EH domain-containing protein 2 | EH-domain containing 2 (Ehd2) | Q8BH64 | 259300 | 5.8 | 3.2 | 0.038 | 0.62 | −1.81 |
| Smoothelin-like protein 1 | smoothelin-like 1 (Smtnl1) | Q99LM3 | 68678 | 2.2 | 1.2 | 0.048 | 0.64 | −1.79 |
| Carboxylesterase 1C | carboxylesterase 1C (Ces1c) | P23953 | 13884 | 9.5 | 5.5 | 0.030 | 0.72 | −1.72 |
| Hemopexin | hemopexin (Hpx) | Q91 × 72 | 15458 | 6.5 | 3.8 | 0.042 | 0.53 | −1.70 |
| Alpha-1-antitrypsin 1-2 | serine (or cysteine) preptidase inhibitor, clade A, member 1B (Serpina1b) | P22599 | 20701 | 12.6 | 7.5 | 0.019 | 0.82 | −1.69 |
| Annexin A2 | annexin A2 (Anxa2) | P07356 | 12306 | 14.4 | 8.8 | 0.023 | 0.62 | −1.64 |
| Phosphorylase b kinase | phosphorylase kinase alpha 1 (Phka1) | P18826 | 18679 | 10.3 | 6.4 | 0.030 | 0.60 | −1.62 |
| Fatty acid-binding protein, adipocyte | fatty acid binding protein 4, adipocyte (Fabp4) | P04117 | 11770 | 36.9 | 23.0 | 0.029 | 0.59 | −1.60 |
| Alpha-1-antitrypsin 1-3 | serine (or cysteine) peptidase inhibitor, clade A, member 1C (Serpina1c) | Q00896 | 20702 | 11.1 | 7.0 | 0.005 | 0.86 | −1.59 |
| Ubiquitin-conjugating enzyme E2 variant 2 | ubiquitin-conjugating enzyme E2 variant 2 (Ube2v2) | Q9D2M8 | 70620 | 4.2 | 2.7 | 0.044 | 0.72 | −1.55 |
| Citrate lyase subunit beta-like protein | citrate lyase beta like (Clybl) | Q8R4N0 | 69634 | 2.8 | 1.8 | 0.020 | 0.68 | −1.55 |
| Ras-related protein Rab-18 | RAB18, member RAS oncogene family (Rab18) | P35293 | 19330 | 2.1 | 1.3 | 0.043 | 0.62 | −1.53 |
| Methylcrotonoyl-CoA carboxylase | methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) (Mccc1) | Q99MR8 | 72039 | 2.3 | 1.5 | 0.023 | 0.81 | −1.51 |
| Profilin | profilin 1 (Pfn1) | Q8CEH8 | 18643 | 12.1 | 8.0 | 0.026 | 0.67 | −1.51 |
| O-acetyl-ADP-ribose deacetylase | MACRO domain containing 1 (Macrod1) | Q922B1 | 107227 | 5.2 | 3.4 | 0.030 | 0.64 | −1.50 |