Study	Reason for exclusion
Agaki 2010	Wrong study design.
Akao 1980	Wrong study design.
Amano 1995	Systematic review, narrative review or overview. Not an original study report.
Anon 1987	Wrong study design.
Anon 2013	Wrong intervention.
Becouarn 1996	Systematic review, narrative review or overview. Not an original study report.
Boone 1994	Systematic review, narrative review or overview. Not an original study report.
Hazama 2002	Wrong study design.
Hiyashibe 1992	Wrong study design.
Iseki 1992	Wrong study population.
Ito 2008a	Wrong comparator.
Ito 2008b	Wrong comparator.
JPRN‐UMIN000001527	Wrong comparator.
JPRN‐UMIN000010045	Wrong study design.
Katsuno 2004	Wrong study design.
Kitamura 1996	Animal study. Wrong study population.
Kobayashi 1995	Systematic review, narrative review or overview. Not an original study report.
Kobayshi 1994	Wrong study design.
Koda 2003	Wrong comparator.
Kudo 2002	Wrong study design.
Li 2019	Wrong study design.
Liu 2014	Animal study. Wrong study population.
Maehara 2012	Systematic review, narrative review or overview. Not an original study report.
Maruyama 2002	Wrong study design.
Miyake 2018	Wrong comparator.
Mukai 2003	Wrong study design.
Nakazato 1986	Wrong study design.
NCT00385970	Wrong comparator.
NCT03716518	Wrong intervention
Nio 1992	Data for colorectal cancer patients not reported separately. Wrong study population.
Nio 1995	Wrong study design.
Okuno 2017	Wrong comparator.
Okuno 2018	Wrong comparator.
Ooshiro 2009	Wrong study design.
Saji 1997	Systematic review, narrative review or overview. Not an original study report.
Sakai 2003	Systematic review, narrative review or overview. Not an original study report.
Shibata 1999a	Systematic review, narrative review or overview. Not an original study report.
Shibata 1999b	Wrong study design.
Shibata 1999c	Wrong study design.
Shibata 2002	Wrong study design.
Shibata 2011	Wrong study design.
Sugiyama 1998	Wrong study design.
Takashima 1988	Wrong study design.
Torisu 1986	Wrong intervention
Torisu 1990	Wrong intervention
Torisu 1991	Systematic review, narrative review or overview. Not an original study report.
Toth 2005	Animal study. Wrong study population.
Tsukida 2018	Wrong study design.
Watanabe 2010	Systematic review, narrative review or overview. Not an original study report.
Yoshikawa 2005	Wrong study design.
Yoshikawa 2006	Wrong study design.
Yoshitani 2009a	Wrong study design.
Yoshitani 2009b	Wrong study design.