Table 1.
Baseline characteristics of patients who required tracheal intubation, by immunocompromised status
| Variable | No IC diagnosis (n=2,710) |
IC, not HCT (n=2,179) |
HCT (n=459) |
p a |
|---|---|---|---|---|
| Age Distribution, n (%) | ||||
| 1 month to 23 months | 1,588 (59) | 529 (24) | 142 (31) | <0.001 |
| 2 years to 5 years | 414 (15) | 559 (26) | 98 (21) | |
| 6 years to 12 years | 335 (12) | 574 (26) | 104 (23) | |
| 13 years to 18 years | 373 (14) | 517 (24) | 115 (25) | |
| Male sex, n (%) | 1,474 (54) | 1,174 (54) | 249 (54) | 0.51 |
| Race, n (%) | ||||
| American Indian/Alaska Native | 36 (1) | 24 (1) | 1 (<1) | <0.001 |
| Asian | 96 (4) | 120 (5) | 11 (2) | |
| Black or African American | 484 (18) | 274 (13) | 54 (12) | |
| Hawaiian or Pacific Islander | 12 (<1) | 3 (<1) | 0 (0) | |
| Hispanic or Latino | 353 (13) | 342 (16) | 49 (11) | |
| White | 1,226 (45) | 976 (45) | 157 (34) | |
| Other/Unspecified | 503 (19) | 440 (20) | 187 (41) | |
| PIM-2 POD, median [IQR] | 1.42 [0.85–4.84] | 2.91 [0.91–4.97] | 4.13 [1.05–5.68] | <0.001 |
| Admission source, n (%) | ||||
| Emergency department | 1,193 (44) | 556 (26) | 39 (9) | <0.001 |
| Hospital ward | 1,062 (39) | 1,306 (60) | 392 (85) | |
| Operating room | 244 (9) | 180 (8) | 16 (3) | |
| Other | 211 (8) | 137 (6) | 12 (3) | |
| Severe sepsis/septic shock, n (%) | 387 (14) | 456 (21) | 173 (38) | <0.001 |
| Asthma diagnosis, n (%) | 208 (8) | 138 (6) | 38 (8) | 0.12 |
| Limitations of care, n (%)b | 230/2,305 (10) | 249/1,933 (13) | 95/402 (24) | <0.001 |
| Pre-intubation support, n (%) | ||||
| None | 1,731 (64) | 1,547 (70) | 245 (53) | <0.001 |
| HFNC | 444 (16) | 315 (15) | 114 (25) | |
| NIPPV | 535 (20) | 317 (15) | 100 (22) |
a
Kruskal-Wallis H test for continuous variables, χ2 test for categorical variables, α = 0.05.
b
Limitations of care data was unavailable for 16% of study participants (No IC diagnosis: 19%; IC, not HCT: 14%; HCT: 13%).
IC: Immunocompromised; HCT: hematopoietic cell transplant; PIM-2: Paediatric Index of Mortality-2; IQR: Interquartile Range; HFNC: high-flow nasal cannula; NIPPV: noninvasive positive pressure ventilation.