Figure 2.

Depiction of the acoustic diagnostic method. (A) Coronary artery disease-score is calculated based on a 3-min recording session from the IC4-L region. Three patient risk factors are combined with acoustic derived data to generate a coronary artery disease-score. A score ≤20 is considered low risk and used to substantiate rule-out for coronary artery disease. (B) The acoustic data are derived from both the systolic and diastolic periods. The acoustic recording is segmented into discrete heart beats and aligned according to S2. Heart beats containing excess noise are filtered out, and the Acoustic-score is calculated. Several acoustic features having different, distinct coronary and myocardial origins are combined into the Acoustic-score.