Table 1.

Schedule of enrolment, interventions, and assessments

Study period	Pre-prehabilitation		Prehabilitation	Hospital admission	Planned surgery	Follow-up
Timepoint from surgery	Week-12	Week-10	Week-9 to -1	Day-1	Day 0	Month +3	Month +6	Month +12
Enrolment
Screening patients for participation	•
Feasibility	•	•	•
Patient information letter for eligible patients	•
Informed consent, feasibility, and randomization		•
Assessments
Baseline characteristics		•
Quality of life questionnaire, SF-36		•		•		•	•	•
Health status questionnaire, EQ-5D-5L		•		•		•	•	•
Pulmonary risk scorea		•		•		•	•	•
Three questions about experiencing physical limitations		•		•		•	•	•
Anxiety and depression screening with HADS		•		•		•	•	•
Nutritional status with MUST* and BMI		•		•		•	•	•
Smoking status		•		•		•	•	•
Resource use, adapted versions of iMCQ/iPCQ				•		•	•	•
Blood sampling				•
Physical tests
Handgrip strength (kg)				•
30-s chair stand test (AMRAP)				•
Maximal inspiratory pressure (cm H2O)				•
Monitoring
NYHA* classification of heart failure (during pre-operative period weekly)		•	•	•		•	•	•
CCS* class of angina pectoris (during pre-operative period weekly)		•	•	•		•	•	•
COVID-19 (during pre-operative period weekly) symptoms/signs		•	•	•
Serious adverse events patient questionnaire				•		•	•	•
Information
COVID-19		•	•
Video’s and animations about scheduled hospital admission and surgery			•	•
Intervention-arm
Personalized teleprehabilitationb			•
Inspiratory muscle training			•
Functional exercise training			•
Psychological support			•
Nutritional support			•
Smoking cessation			•
Adherence to intervention			•

AMRAP, as many repetitions as possible; BMI, body mass index; EQ-5D-5L, EuroQol five-dimensional five-level questionnaire; CCS, Canadian Cardiovascular Society; HADS, Hospital Anxiety and Depression Scale; iMCQ, iMedical consumption questionnaire; iPCQ, iProductivity cost questionnaire, pulmonary risk score; MUST, malnutrition universal screening tool; NYHA, New York Heart Association; SF-36: 36-item short form health survey.

^aThe pulmonary risk score is based on several risk factors for post-operative pulmonary complications, see the section addressing inspiratory muscle training (IMT).

^bExplained in more detail in Table 2, only for patients randomized to the intervention arm.